The Ancient Vampires were the ones created directly by the Runes. They slowly entered a hibernation state when the extinction event took place. For a small period of time before going into slumber, they worked together with a group of humans sharing knowledge about the Draco technology so that the humans could restore their full power and re-awaken them.
Ancients proved to be immortal and remained asleep, waiting for a breakthrough in human technology to set them free.
Left alone, without vampire intervention, humans went their way for a hundred years of pure human evolution. World War I, World War II, overpopulation and all that is known since 1910 until present day.